See how your logged doses may build up and decline over time.
GlucoPal models an estimated medication rhythm from your logged doses and published pharmacokinetic parameters. It is an educational estimate, not a measurement of medication in your blood and not a tool for changing your dose.
Free to download · Estimated level chart requires GlucoPal Pro
Can you change the medication chart’s time range?
Yes. GlucoPal’s estimated medication-level chart offers 7-day, 30-day, 90-day and all-history views. Switch the range to review a recent week or a longer stretch of logged doses.
The forecast chart requires GlucoPal Pro. It uses the doses and timing in your records to model a curve. The separate weight chart uses dose colors and labels, with 30-day, 90-day, 180-day and all-history ranges.
These charts provide context for your records. They do not measure your blood concentration or establish the cause of a symptom.
Explore GlucoPal’s charts and other features
See an estimate of your medication level over time.
GlucoPal uses your logged doses and published pharmacokinetic parameters to model how medication may accumulate and decline over time. The chart is an estimate, not a measurement of medication in your body.
Estimated Medication
Zepbound® · tirzepatide · weekly injection
- Est. level now
- 78%
- Next dose
- in 3 days
- Current dose
- 10 mg
Built on published half-lives
The model uses medication-specific pharmacokinetic parameters rather than treating every GLP-1 the same.
Pills and injections alike
Weekly injections and daily pills have different modeled absorption and dosing rhythms, so GlucoPal charts them differently.
Shows dose accumulation
Because a new dose can arrive before the previous dose has fully cleared, the model shows repeated doses accumulating toward a repeating pattern.
Educational estimate only. It does not measure your blood level, establish what is causing a symptom, or determine when to change your dose. Follow your prescriber’s instructions.
Pharmacokinetics, minus the textbook.
GlucoPal applies a pharmacokinetic model to the medication, dose, and timing you log. The result is an estimate of a dosing pattern, not a measured concentration in your body.
You log your dose
Medication, amount, and time — the same quick log you already make in GlucoPal.
We model absorption and decay
The model uses medication-specific pharmacokinetic parameters, including absorption timing and elimination half-life.
Repeated doses form a curve
When a new dose arrives before the previous dose has fully cleared, the model adds the overlapping doses into one estimated curve.
Each medication uses its own published parameters.
GLP-1 medications differ in absorption and elimination. These approximate values are inputs to an educational model; individual pharmacokinetics vary.
| Medication | Brand names | How it's taken | Half-life | Time to peak | Approx. five half-lives |
|---|---|---|---|---|---|
| Tirzepatide | Zepbound, Mounjaro | Weekly injection | ~5–6 days | ~24–72 hours | ~25–30 days |
| Semaglutide (injection) | Wegovy, Ozempic | Weekly injection | ~7 days | ~1–3 days | ~5 weeks |
| Semaglutide (oral) | Rybelsus | Daily pill | ~7 days | ~1 hour | ~5 weeks |
| Retatrutide | In clinical trials | Weekly injection | ~6 days | ~24–48 hours | ~30 days |
| Dulaglutide | Trulicity | Weekly injection | ~5 days | ~24–48 hours | ~25 days |
| Liraglutide | Saxenda, Victoza | Daily injection | ~13 hours | ~11 hours | ~3 days |
Approximate values from published pharmacokinetic data; individual results vary. The last column is a rough five-half-life reference after a single dose, not a claim that the medication is completely absent. The chart is for education only and should not be used to change your dose or schedule.
Medication levels, answered.
How long does Mounjaro or Zepbound stay in your system?
Tirzepatide — the active ingredient in Mounjaro and Zepbound — has an elimination half-life of approximately 5–6 days in current Zepbound prescribing information. Roughly half of a dose remains after one half-life, and a single dose takes several half-lives to mostly clear. GlucoPal uses your logged doses to model that pattern over time.
What is the half-life of semaglutide (Wegovy, Ozempic)?
Semaglutide has an elimination half-life of about 7 days, which supports once-weekly dosing for injected semaglutide. After the last dose, semaglutide can remain in circulation for several weeks.
What does “steady state” mean for GLP-1 medications?
With repeated dosing, a new dose can arrive before the previous dose has fully cleared. Over time, the amount entering and leaving the body approaches a repeating pattern called steady state. GlucoPal visualizes an estimate of that accumulation from the doses you log.
Why does the estimated medication level rise during the first few weeks?
The model can rise during the first weeks because repeated doses overlap before earlier doses fully clear. The chart is a pharmacokinetic estimate; it does not measure your blood level or establish why you feel a particular symptom.
Does GlucoPal measure my actual blood level?
No. GlucoPal calculates an educational estimate using your logged doses and published pharmacokinetic parameters such as absorption time and elimination half-life. It is not a blood test, cannot determine what is causing a symptom, and should not be used to change your dose or schedule.
Which medications does the levels feature support?
GlucoPal models estimated levels for tirzepatide (Zepbound, Mounjaro), semaglutide injections (Wegovy, Ozempic), oral semaglutide (Rybelsus), liraglutide (Saxenda, Victoza), dulaglutide (Trulicity), and retatrutide. Retatrutide remains investigational.
Sources
- Clinical Pharmacokinetics of Semaglutide (PubMed)
- FDA Prescribing Information — Semaglutide
- FDA Prescribing Information — Zepbound (tirzepatide)
- Population Pharmacokinetics of Tirzepatide (PubMed)
- Tirzepatide Once Weekly for the Treatment of Obesity (NEJM, 2022)
- Triple-Hormone-Receptor Agonist Retatrutide for Obesity (NEJM, 2023)
Want the bigger picture? Read our GLP-1 guides or see everything else GlucoPal tracks.
You take your GLP-1s. We'll take care of the rest.
