How Long Does Wegovy Stay in Your System?
Wegovy stays in your system for about 5 to 7 weeks after the last 2.4 mg dose, per its FDA label. Semaglutide's half-life is about 1 week, so levels fall below 5% of the steady level in about 5 weeks.
Looking for weight loss by month instead? Use the Wegovy weight loss calculator.
From the Wegovy FDA label · Free, no sign-up
At a glance
- Half-life
- about 1 week
- Peak after a dose
- 1 to 3 days
- Steady state
- about 5 weeks
- Below 5% after stopping
- about 5 weeks
See your real levels
GlucoPal charts your estimated level from the doses you actually log.
Read the chart as a table
Wegovy 2.4 mg, last dose on day 49. Modeled amounts absorbed, not blood levels.
| Timepoint | Estimated amount (mg) | % of steady peak |
|---|---|---|
| Day 0 on treatment | 0.00 | 0.0% |
| Day 1 on treatment | 1.5 | 41.5% |
| Day 2 on treatment | 1.8 | 47.5% |
| Day 3 on treatment | 1.7 | 45.4% |
| Day 7 on treatment | 1.1 | 31.1% |
| Day 14 on treatment | 1.7 | 46.6% |
| Day 21 on treatment | 2.0 | 54.4% |
| Day 28 on treatment | 2.2 | 58.3% |
| Day 35 on treatment | 2.2 | 60.2% |
| Day 42 on treatment | 2.3 | 61.2% |
| Day 49, last dose | 2.3 | 61.7% |
| 1 day after the last dose | 3.6 | 97.4% |
| 2 days after the last dose | 3.6 | 98.1% |
| 3 days after the last dose | 3.4 | 91.2% |
| 7 days after the last dose | 2.3 | 61.9% |
| 14 days after the last dose | 1.1 | 31.0% |
| 21 days after the last dose | 0.57 | 15.5% |
| 28 days after the last dose | 0.29 | 7.7% |
| 35 days after the last dose | 0.14 | 3.9% |
Educational estimate, not a blood level or medical advice. Follow your prescriber's instructions.
What is the half-life of Wegovy?
Wegovy's elimination half-life is about 1 week, per the FDA label: that is how long it takes for the amount of semaglutide in your body to halve. Levels peak 1 to 3 days after a dose, and on the label schedule (a weekly injection) they reach steady state about 5 weeks after the first dose. After a last dose they fall below 5% of that steady level in about 5 weeks.
Between scheduled doses, levels swing between a peak and a trough of about 62% of that peak, which is why the chart looks like a sawtooth rather than a flat line. The label also reports that 89% of each dose is absorbed into circulation; the chart's mg figures build that in.
What if you miss a dose of Wegovy?
The Wegovy label uses a 48-hour rule: take a missed injection as soon as possible if the next scheduled dose is more than 2 days away, and skip it if less. For the daily tablet, the label says to skip a missed day and take the next dose the following day.
That window is the half-life doing the work: with about 1 week of half-life, a late dose still lands on a meaningful base. This is the label's instruction to prescribers, not our advice; if you have missed a dose, your own label and prescriber are the authority.
Do all three Wegovy forms leave your system at the same rate?
Wegovy now comes as the 2.4 mg weekly injection, the higher 7.2 mg Wegovy HD weekly injection, and the 25 mg daily tablet. All three are semaglutide, so all three share the one-week half-life and the weeks-long taper; what differs is the dosing rhythm and how much reaches your blood. The tablet is taken daily because of how the oral form absorbs (well under 1% of the swallowed mg), not because it leaves the body faster.
That has a counterintuitive consequence the calculator makes visible: stop the daily tablet and the accumulated semaglutide still takes about a month to fall below 5% of its steady level, nearly the same goodbye as the weekly injection.
FAQ
Is the Wegovy half-life the same as Ozempic?
Yes. Wegovy and Ozempic are both semaglutide, so the elimination half-life of about 1 week is identical; the brands differ in approved doses and indication, not in how fast the molecule leaves.
Is it safe to restart Wegovy after a 3-week break?
That is your prescriber's call, and the label is the reference. A single missed injection follows the 2-day rule above; if 2 or more consecutive doses are missed, the Wegovy label says to reinitiate dose escalation at a lower dosage to reduce the risk of stomach side effects. The chart shows why: three weeks after a last dose, about 16% of your steady peak level is left, so a full-dose restart would land on a mostly empty base.
Is the half-life of the Wegovy pill the same as the injection?
Yes. The 25 mg daily tablet and the 2.4 mg weekly injection are both semaglutide, so the half-life of about 1 week is identical. What differs is absorption: the Rybelsus label reports that only 0.4% to 1% of a swallowed semaglutide tablet reaches circulation, against 89% for the injection, which is why the tablet is a larger dose taken daily. The calculator charts the absorbed amount for both forms.
Why does Wegovy feel weaker right before the next dose?
Two things stack. By the end of the week your level really is at its trough, about 62% of the post-dose peak. But blood level is not the same as felt effect: appetite suppression has its own timetable, and receptors adjust, so the day-6 dip many people report is real without meaning the medication is gone.
Does a higher Wegovy dose take longer to leave your system?
Not meaningfully. Wegovy is eliminated proportionally: the amount cleared per day is a fixed fraction of what remains, so every dose falls along the same percentage curve on the same timeline. A higher dose means more semaglutide at every point, not a longer goodbye.
Are these numbers my actual blood levels?
No. The curve is a population estimate built from the FDA label's median half-life and absorption figures: anyone who took the same doses on the same days would see the same chart. Individual metabolism runs faster or slower than the median, so treat it as the shape and rough scale of your levels, not a measurement.
Is this calculator free, and do I need to sign up?
Yes, it is free, and no sign-up or email is required. You see the full curve and the estimated clearance timeline instantly. The GlucoPal iOS app it comes from is also free to download.
Related calculators
- Wegovy dosage chartThe label steps from 0.25 mg to 2.4 mg, and the Wegovy pill schedule.
- GLP-1 half-life calculatorAll nine medications side by side: build-up, steady state, and clearance.
- Wegovy weight loss calculatorAll three forms with their own trials: 2.4 mg, 7.2 mg HD, and the tablet.
- Ozempic half-lifeThe same semaglutide clock at Ozempic doses.
- Semaglutide dose calculatorYour prescribed mg converted to syringe units for a compounded vial.
Sources
Built and maintained by GlucoPal, the free app for iPhone and Android for tracking GLP-1 weight loss medications. All pharmacokinetic figures were read directly from the current FDA label on DailyMed on 27 August 2026 and re-checked on 2 October 2026.
You take your GLP-1s. We'll take care of the rest.
