Wegovy Half-Life Calculator
Wegovy is semaglutide, the longest-lasting of the GLP-1 weight loss medications: a one-week half-life, and the label itself says 5 to 7 weeks in circulation after the last 2.4 mg dose. See your estimated level at any day.
Free · instant chart · no sign-up or email · built on the Wegovy FDA label
Wegovy half-life chart: estimated mg in your body, day by day
Estimated semaglutide in your body, day 56 after your first dose
steady rhythm: ~3.7 mg peak, ~2.3 mg trough
Free · No account required · iPhone
Quick answer: Wegovy's elimination half-life is approximately 1 week. The label states semaglutide remains in circulation for about 5 to 7 weeks after the last 2.4 mg injection; this calculator's 5%-of-steady-level line falls at about 5 weeks, inside that window. Building up, levels reach steady state in about 5 weeks. The one-week clock belongs to the molecule, so the 2.4 mg injection, the 7.2 mg Wegovy HD dose, and the 25 mg daily tablet all follow it.
Educational estimate only, not medical advice. Individual pharmacokinetics vary, and blood level is not the same thing as appetite effect. Never change your dose or schedule without your prescriber.
The Wegovy half-life arithmetic
Wegovy is semaglutide, with an elimination half-life of about 1 week and peak levels 1 to 3 days after a dose, per the FDA label. On the label schedule (a weekly injection), levels reach steady state about 5 weeks after the first dose, and after a last dose they fall below 5% of that steady level in about 5 weeks.
Between scheduled doses, levels swing between a peak and a trough of about 62% of that peak, which is why the calculator's chart looks like a sawtooth rather than a flat line. The label also reports that 89%of each dose is absorbed into circulation; the calculator's mg figures build that in.
What the Wegovy label says about a missed dose
The Wegovy label uses a 48-hour rule: take a missed injection as soon as possible if the next scheduled dose is more than 2 days away, and skip it if less. For the daily tablet, the label says to skip a missed day and take the next dose the following day.
That window is the half-life doing the work: with about 1 weekof half-life, a late dose still lands on a meaningful base. This is the label's instruction to prescribers, not our advice; if you have missed a dose, your own label and prescriber are the authority.
One clock, three Wegovy forms
Wegovy now comes as the 2.4 mg weekly injection, the higher 7.2 mg Wegovy HD weekly injection, and the 25 mg daily tablet. All three are semaglutide, so all three share the one-week half-life and the weeks-long taper; what differs is the dosing rhythm and how much reaches your blood. The tablet is taken daily because of how the oral form absorbs (well under 1% of the swallowed mg), not because it leaves the body faster.
That has a counterintuitive consequence the calculator makes visible: stop the daily tablet and the accumulated semaglutide still takes about a month to fall below 5% of its steady level, nearly the same goodbye as the weekly injection.
FAQ
How long does Wegovy stay in your system after stopping?
The label's own answer: semaglutide remains in circulation for about 5 to 7 weeks after the last 2.4 mg dose. On this calculator's curve, levels fall below 5% of the steady level about 5 weeks after the last injection, with trace amounts persisting toward the label's outer bound.
Is the Wegovy half-life the same as Ozempic?
Yes. Wegovy and Ozempic are both semaglutide, so the elimination half-life of about 1 week is identical; the brands differ in approved doses and indication, not in how fast the molecule leaves.
Is it safe to restart Wegovy after a 3-week break?
That is your prescriber's call, and the label is the reference. A single missed injection follows the 2-day rule above; if 2 or more consecutive doses are missed, the Wegovy label says to reinitiate dose escalation at a lower dosage to reduce the risk of stomach side effects. The chart shows why: three weeks after a last dose, about 16% of your steady peak level is left, so a full-dose restart would land on a mostly empty base.
Is the half-life of the Wegovy pill the same as the injection?
Yes. The 25 mg daily tablet and the 2.4 mg weekly injection are both semaglutide, so the half-life of about 1 week is identical. What differs is absorption: the Rybelsus label reports that only 0.4% to 1% of a swallowed semaglutide tablet reaches circulation, against 89% for the injection, which is why the tablet is a larger dose taken daily. The calculator charts the absorbed amount for both forms.
Why does Wegovy feel weaker right before the next dose?
Two things stack. By the end of the week your level really is at its trough, about 62% of the post-dose peak. But blood level is not the same as felt effect: appetite suppression has its own timetable, and receptors adjust, so the day-6 dip many people report is real without meaning the medication is gone.
Does a higher Wegovy dose take longer to leave your system?
Not meaningfully. Wegovy is eliminated proportionally: the amount cleared per day is a fixed fraction of what remains, so every dose falls along the same percentage curve on the same timeline. A higher dose means more semaglutide at every point, not a longer goodbye.
Are these numbers my actual blood levels?
No. The curve is a population estimate built from the FDA label's median half-life and absorption figures: anyone who took the same doses on the same days would see the same chart. Individual metabolism runs faster or slower than the median, so treat it as the shape and rough scale of your levels, not a measurement.
Is this calculator free, and do I need to sign up?
Yes, it is free, and no sign-up or email is required. You see the full curve and the estimated clearance timeline instantly. The GlucoPal iOS app it comes from is also free to download.
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Sources
This free calculator is built and maintained by GlucoPal, the free iPhone app for tracking GLP-1 weight loss medications. All pharmacokinetic figures were read directly from the current FDA label on DailyMed on 27 August 2026.
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