Foundayo Half-Life Calculator

Foundayo is orforglipron, with an elimination half-life of 29 to 49 hours and peak levels 4 to 8 hours after a dose, per the FDA label. On the label schedule (a daily pill), levels reach steady state about 8 days after the first dose, and after a last dose they fall below 5% of that steady level in about 7 days.

Between scheduled doses, levels swing between a peak and a trough of about 72% of that peak, which is why the calculator's chart looks like a sawtooth rather than a flat line. The label also reports that 77%of each dose is absorbed into circulation; the calculator's mg figures build that in.

The Foundayo label instructs that a missed dose be taken as soon as possible, then the regular once-daily schedule resumed.

That window is the half-life doing the work: with 29 to 49 hoursof half-life, a late dose still lands on a meaningful base. This is the label's instruction to prescribers, not our advice; if you have missed a dose, your own label and prescriber are the authority.

Where a stopped weekly injection tapers over a month or more, a stopped Foundayo course is largely gone within days: below half in about two days, below 5% in about a week. The same short clock works in your favor when starting, since steady state arrives in roughly a week rather than a month.

The trade-off is that consistency matters more day to day. Miss several daily pills and the base genuinely drains, which is why the label pairs flexible dosing (with or without food) with a simple take-it-when-you-remember missed-dose rule.